Metformin as a potential longevity medication: where do we stand?

Humans have sought interventions for lifespan extension for millennia, though over the last century, this quest has taken on a more formal, scientific approach. Since the early 20th century, such research has led to the identification of several potential “longevity molecules,”¹ and in recent years, metformin has emerged as one of the most discussed candidates for this role, generating both excitement and skepticism within the scientific community.

While many are familiar with metformin as a common medication for the treatment of type 2…