An emerging role for creatine supplementation in the treatment of depression

Despite the existence of an arsenal of medications that target the neurotransmitters in the brain thought to be responsible for mood disorders, about 30% of individuals with major depressive disorder remain treatment-resistant. This points to other possible factors that may contribute to the condition.

Research to date has implicated impaired energy metabolism as a potential culprit, as the brain requires enormous amounts of energy to function normally. This, in turn, would suggest that interventions known to boost cellular energy production…